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Guacamole is the nickname of a strain of handwavium particularly suited to biomodification. Occasionally referred to as Green-Strain Handwavium or Green Goo, it is the same color and texture as the Mexican dip of the same name.

Warning label required to be placed on prepackaged Guacamole

Before the invention of the Catgirling Machine, the replacement of avocado-based guacamole with handwavium Guacamole at parties was the leading cause of unwanted biomodifications. The first seventeen people to have been biomodded, including Natalie Baker and Shuko, are known to have obtained their biomods from unknowingly eating from a bowl of Guacamole at a science-fiction convention in 2008 (usually referred to as "THAT Con".)